Protein-ligand Interactions: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) – Hans-Joachim Bohm
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost …
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Ebook rating average
Related Books to : Protein-ligand Interactions: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) – Hans-Joachim Bohm
Related PDF Documents
Contact their sites if you have any question about their content.
Molecular recognition in protein-ligand complexes is re- ... ligand interactions serve a particular purpose, for example an ... medicinal chemistry. ... Hans-Joachim Bohm, born in 1956 in Frankfurt am Main, studied ... methods for structure-based drug design. ... with several rotatable bonds and can, in principle, adopt a po-.
Edited by Hans-Joachim Bohm and Gisbert Schneider ... Preface. The present volume of the series "Methods and Principles in Medicinal Chemistry" fo- cuses on ... Structure-based design and molecular modelling were introduced to Medici- ... 10.4 Spatial Location of Putative Interaction Sites Between Ligands and Proteins.
shift in drug discovery paradigms happened: combinatorial chemistry ... Hans-Joachim Böhm at BASF in the early 1990's, was a significant ... Methods and Principles in Medicinal Chemistry, Mannhold, R, Kubinyi, H, and ... Metz G, Ottleben H, and Vetter D, in: Protein-Ligand Interactions From Molecular Recognition to. Drug...
Keywords: Computer-aided drug design, template library, drug-like filters, ab initio charges, docking, protein-ligand interactions, binding free energy, molecular...